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Our team is developing precision medicines for oncology and other therapeutic areas.

We are exclusively focused on drugging transcription factors to fully unlock the therapeutic potential of this previously elusive target class. By leveraging our integrated discovery platform of capabilities, we identify novel validated ligands to the undrugged proteome. 

Our lead program, FX-909, is a first-in-class orally available small molecule inhibitor of PPARG, a master regulator of the luminal lineage, that is initially being developed for locally advanced or metastatic urothelial cancer. FX-909 has achieved clinical proof-of-concept in a Phase 1A study as a monotherapy and is actively dosing patients in a Phase 1B. Our second lead program, FX-111, is a novel and highly differentiated potent and selective degrader for ARON, the transcriptionally active, hormone-bound androgen receptor.

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Flare Therapeutics is a groundbreaking brand that is revolutionizing the approach to treating diseases. Their pioneering research has led them to uncover a hidden region, known as the 'switch site,' which holds the key to transcription factors. Unlike previous studies, their research opens up new possibilities for drug discovery. Currently, Flare Therapeutics is focused on precision oncology in their pipeline. They have developed small molecules that aim to regain transcriptional control that is often hijacked by cancer. By intervening at the switch site, they aim to restore normal cellular functioning and combat the disease. What sets Flare Therapeutics apart is not only their cutting-edge scientific advancements but also their exceptional team. Comprising individuals with intensity, empathy, determination, and brilliance, this team is constantly pushing boundaries and seeking new talent to join them. They have been recognized as one of the Best Workplaces for 2023 by Inc. Magazine. With a commitment to making a difference in the lives of patients, Flare Therapeutics is blazing a trail in the field of transcription factors and offering innovative solutions to tackle diseases head-on.

Flare Therapeutics

Biotechnology and Pharmaceuticals

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## Qualifications:

•Extensive programming project experience in DIOTECH/pharmaceutical companies or CROs, with a strong background in oncology solid tumor clinical trials

•Advanced knowledge of SAS/Base, SAS/Macro, SAS/STAT, SAS/Graph, and SAS/SQL in a Windows environment, with demonstrated mastery of SAS/STAT procedures

•Strong experience with CDISC SDTM and ADAM standards and familiarity with eCTD submission requirements

•Demonstrated success in managing programming deliverables across multiple studies and vendors

•Deep understanding of drug development and the biopharmaceutical industry

•Proven ability to manage multiple, competing priorities in a dynamic environment

•Excellent communication, collaboration, and organizational skills

•Self-motivated and results-oriented, with the ability to meet tight timelines

Advanced experience with:

•Constructing technical programming specifications

•Relational databases

•Good Clinical Practices (GCP)

•Good Programming Practices (GPP)

•21 CFR Part 11 Standards

•Integrated summary safety/efficacy analyses

•Safety data and coding dictionaries (MedDRA)

## Responsibilities:

•Development and validation of technical programming specifications and programs

•Generation of SDTM and ADaM datasets

•Production of SAP-specific tables, listings, and figures

•Management and documentation of all statistical programming activities

•Implementation of process and technology improvements to enhance efficiency and quality

•Contribute to the development and maintenance of SOPs and guidelines for statistical programming and ensure adherence across projects

•Coordinate end-to-end programming deliverables in collaboration with cross-functional team members and vendors

•Collaborate closely with internal stakeholders (Biostatistics, Clinical, Medical, Regulatory) and external partners (Full-Service and Functional Service Providers)

•Ensure outsourced programming activities are performed according to GCP, approved SOPs, and study protocols

•Monitor vendor deliverables and quality, escalating issues when needed

•Support study- and program-level audit and inspection readiness activities

Fractional Director Statistician/Programmer

Director level

A command-driven software package used for statistical analysis and data visualization

Chief Data Officer

Senior Data Scientist

Director of Program Management

Our team ‘brings it’ every day for one mission: to conquer transcription factors and create cutting-edge medicines.

Flare Therapeutics is lighting up new frontiers in biotech by tackling transcription factors – an elusive protein class long considered “undruggable.” Leveraging our proteomic and mass spectrometry platform, proprietary electrophilic compound library and deep expertise, we are unlocking the potential of these critical proteins to address unmet needs in oncology and beyond.

Our lead program, FX-909, is a first-in-class investigational orally bioavailable small molecule inhibitor of PPARG, a master regulator of the luminal lineage in advanced urothelial cancer that is currently in a Phase I study. We have also advanced a second program with a differentiated mechanism for prostate cancer entering the Investigational New Drug (IND)-enabling stage, alongside a pipeline of earlier-stage programs targeting transcription factors involved in oncology and other therapeutic areas.

Trailblazing the path to drugging transcription factors to discover precision medicines for cancer & other disease areas

Title - SAS Programming Director, Contract Position
  
  
Part time: 20 hours/week
  
  
Contract – 1 yr Duration
  
  
Qualifications:
  
  

- Extensive programming project experience in DIOTECH/pharmaceutical companies or CROs, with a strong background in oncology solid tumor clinical trials
- Advanced knowledge of SAS/Base, SAS/Macro, SAS/STAT, SAS/Graph, and SAS/SQL in a Windows environment, with demonstrated mastery of SAS/STAT procedures
- Strong experience with CDISC SDTM and ADAM standards and familiarity with eCTD submission requirements
- Demonstrated success in managing programming deliverables across multiple studies and vendors
- Deep understanding of drug development and the biopharmaceutical industry
- Proven ability to manage multiple, competing priorities in a dynamic environment
- Excellent communication, collaboration, and organizational skills
- Self-motivated and results-oriented, with the ability to meet tight timelines

Advanced experience with:
  
  

- Constructing technical programming specifications
- Relational databases
- Good Clinical Practices (GCP)
- Good Programming Practices (GPP)
- 21 CFR Part 11 Standards
- Integrated summary safety/efficacy analyses
- Safety data and coding dictionaries (MedDRA)

Responsibilities:
  
  

- Development and validation of technical programming specifications and programs
- Generation of SDTM and ADaM datasets
- Production of SAP-specific tables, listings, and figures
- Management and documentation of all statistical programming activities
- Implementation of process and technology improvements to enhance efficiency and quality
- Contribute to the development and maintenance of SOPs and guidelines for statistical programming and ensure adherence across projects
- Coordinate end-to-end programming deliverables in collaboration with cross-functional team members and vendors
- Collaborate closely with internal stakeholders (Biostatistics, Clinical, Medical, Regulatory) and external partners (Full-Service and Functional Service Providers)
- Ensure outsourced programming activities are performed according to GCP, approved SOPs, and study protocols
- Monitor vendor deliverables and quality, escalating issues when needed
- Support study- and program-level audit and inspection readiness activities

We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.

SAS Programming Director, Contractor  (Part-Time)

Cambridge

12-month Fractional Director Statistician/Programmer to manage programming deliverables for biotech company

Flare Therapeutics

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