Schedule a call →

<p>Interview fractional leaders this week for <strong>free</strong>!</p>

Entrada Therapeutics

Entrada Therapeutics is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible. Through proprietary and versatile approaches, Entrada is advancing a robust development portfolio of genetic medicines for the potential treatment of neuromuscular and inherited retinal diseases, among others. Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne muscular dystrophy (DMD) who are exon 44, 45, 50 and 51 skipping amenable. Entrada has partnered with Vertex Pharmaceuticals to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1 (DM1).

2026 represents a catalyst-rich period for Entrada. We expect multiple clinical data readouts as we advance several DMD programs across the U.K., EU, and U.S. By year-end 2026, we anticipate four clinical-stage programs in our DMD franchise (ENTR-601-44, ENTR-601-45, ENTR-601-50, and ENTR-601-51). These programs are complemented by the ongoing clinical progress of our DM1 collaboration with Vertex (VX-670).

We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

**Our Values:**
- **Humanity** - We genuinely care about patients and about one another.
- **Tenacity** - We are relentless and persistent in the pursuit of developing therapies for patients.
- **Creativity** - We are creative problem solvers.
- **Collaboration** - We are more than the sum of our parts.
- **Curiosity** - We have a growth mindset and push conventional thought and theory.

## The Opportunity

Reporting to the Head of Biometrics, this individual will lead daily statistical activities and support the development of statistical approaches for clinical trials in a part-time capacity of about 20 hours per week.

## Responsibilities

- Support or lead statistical strategy for assigned drug programs, including input to clinical development plans, clinical study concepts and protocols design, SAPs, clinical study reports, regulatory documentation and associated publications.
- Accountable for oversight of the production of biostatistics deliverables (TFLs, including planned, post-hoc, and/or exploratory analyses) as performed by external resources.
- Review the randomization procedures and oversight of the production of randomization lists.
- Oversee outsourced statistical CRO activities and deliverables, ensuring high quality and timely delivery.

## Requirements

- Ph.D. in Statistics or a related field, with 10 + years of experience in statistical analysis within the biotech/pharmaceutical industry.
- Experience with a broad array of statistical approaches and experience in proposing novel approaches to support acceleration of clinical programs, specifically within rare disease indications.
- Solid understanding of regulatory guidelines on drug development, regulatory submissions, and statistical practice.
- Strong statistical programming skills (R, SAS, Python).
- Understanding of regulatory guidelines related to submission of datasets using CDISC, development of SDTM and ADaM specifications.
- Strong vendor management experience.
- Previous experience in Neuromuscular, Ophthalmology or related TA is preferred.
- Excellent verbal and written communication skills, coupled with strong attention to detail and proactive mindset.
- This is a long-term contract position based remotely in the US, with preference given to local New England based candidates. This role is for an expected 20-25 hours per week.

Total Rewards & HR Operations

Alex Bonanno

Manager, Total Rewards & People Operations

Rose Lewis

Director, Head of Total Rewards & HR Operations

Biostatistician Lead Consultant

Marketing Consultant

A clear and powerful object-oriented programming language, comparable to Perl, Ruby, Scheme, or Java.

Python

Statistical Analysis

Clinical Trials

Clinical Development

A command-driven software package used for statistical analysis and data visualization

Headquartered in Boston’s Seaport community, Entrada Therapeutics is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible. Our Endosomal Escape Vehicle (EEV™)-therapeutics are designed to enable the efficient intracellular delivery of a wide range of therapeutics into a variety of organs and tissues, resulting in an improved therapeutic index. Through this proprietary, versatile and modular approach, we are advancing a robust development portfolio of RNA-, antibody- and enzyme-based programs for the potential treatment of neuromuscular, ocular, metabolic and immunological diseases, among others. Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne who are exon 44, 45, 50 and 51 skipping amenable. Entrada has partnered to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1.

For more information about Entrada, please visit our website, www.entradatx.com

Overcoming the challenge of intracellular target access to transform the treatment of devastating diseases

## **The Organization**

What's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible. Through proprietary and versatile approaches, Entrada is advancing a robust development portfolio of genetic medicines for the potential treatment of neuromuscular and inherited retinal diseases, among others. Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne muscular dystrophy (DMD) who are exon 44, 45, 50 and 51 skipping amenable. Entrada has partnered with Vertex Pharmaceuticals to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1 (DM1).

2026 represents a catalyst-rich period for Entrada. We expect multiple clinical data readouts as we advance several DMD programs across the U.K., EU, and U.S. By year-end 2026, we anticipate four clinical-stage programs in our DMD franchise (ENTR-601-44, ENTR-601-45, ENTR-601-50, and ENTR-601-51). These programs are complemented by the ongoing clinical progress of our DM1 collaboration with Vertex (VX-670).

We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

## **The Perfect Addition to Our Team**

You are passionate about clinical trial research and driven to advance drug development through rigorous analytics. With a strong foundation in statistics and clinical methodologies, you combine classical techniques with cutting-edge innovations. You thrive in fast-paced settings, handle competing priorities with ease, and eagerly step in where needed.

## **The Opportunity**

Reporting to the Head of Biometrics, this individual will lead daily statistical activities and support the development of statistical approaches for clinical trials in a part-time capacity of about 20 hours per week.

## **Responsibilities**

- Support or lead statistical strategy for assigned drug programs, including input to clinical development plans, clinical study concepts and protocols design, SAPs, clinical study reports, regulatory documentation and associated publications.
- Accountable for oversight of the production of biostatistics deliverables (TFLs, including planned, post-hoc, and/or exploratory analyses) as performed by external resources.
- Review the randomization procedures and oversight of the production of randomization lists.
- Oversee outsourced statistical CRO activities and deliverables, ensuring high quality and timely delivery.

## **The Necessities**

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

- **Humanity** - We genuinely care about patients and about one another.
- **Tenacity** - We are relentless and persistent in the pursuit of developing therapies for patients.
- **Creativity** - We are creative problem solvers.
- **Collaboration** - We are more than the sum of our parts.
- **Curiosity** - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

- Ph.D. in Statistics or a related field, with 10 + years of experience in statistical analysis within the biotech/pharmaceutical industry.
- Experience with a broad array of statistical approaches and experience in proposing novel approaches to support acceleration of clinical programs, specifically within rare disease indications.
- Solid understanding of regulatory guidelines on drug development, regulatory submissions, and statistical practice.
- Strong statistical programming skills (R, SAS, Python).
- Understanding of regulatory guidelines related to submission of datasets using CDISC, development of SDTM and ADaM specifications.
- Strong vendor management experience.
- Previous experience in Neuromuscular, Ophthalmology or related TA is preferred.
- Excellent verbal and written communication skills, coupled with strong attention to detail and proactive mindset.
- This is a long-term contract position based remotely in the US, with preference given to local New England based candidates. This role is for an expected 20-25 hours per week. #LI-JF1 #LI-Remote

## **Equal Opportunity Employer**

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

## **Third Party Staffing Agencies**

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

## **Privacy Statement**

Entrada Therapeutics, Inc. (the "**Entrada**," "**we,**" "**us,**" or "**our**") respects your privacy and we want you to be familiar with how we collect, use, share, or otherwise process, your Personal Information. Please reference our privacy statement **here** to understand how and when your data is being used.

Boston

The role involves leading statistical activities for clinical trials on a part-time basis, reporting to the Head of Biometrics. Responsibilities include developing statistical strategies, overseeing biostatistics deliverables, and managing outsourced CRO activities. The position requires a Ph.D. in Statistics and 10+ years of experience in the biotech/pharmaceutical industry.

Entrada Therapeutics

Jobs

Fractional Biostatistician Lead

About this page