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Aphios Corporation is seeking a Fractional CFO to join their team remotely. The role involves financial leadership in a biotechnology company focused on developing therapeutics and technology platforms.

Explore Aphios’ hybrid model of drug development and licensing powered by 87 patents and $50M in funding.

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Aphios is a leading brand in the field of green biotechnology and nanotechnology drug delivery platforms. They develop enhanced therapeutic products for health maintenance, disease prevention, and the treatment of certain cancers, infectious diseases, and CNS disorders like Alzheimer's Disease. The company was founded in 1993 with a focus on developing enabling technology platforms and investigating natural therapeutics. They utilize advanced scientific techniques to improve drug delivery, accelerate drug discovery and manufacturing, remove harmful pathogens, and explore biofuel solutions. Aphios has a rich pipeline of ethical and over-the-counter products, with 36 issued patents and 15 pending patents. They are committed to developing natural solutions for human health and have lead therapeutic products under development for various conditions. Aphios has established partnerships with major pharmaceutical and biotechnology companies and supplies specialty research chemicals to distributors. They are actively seeking partners and investors to further develop their technology platforms and therapeutic products.

Aphios Corporation

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Aphios, a biotechnology company, is leading the way in developing green enabling technology platforms and enhanced therapeutics for health maintenance and well-being as well as the prevention and treatment of human diseases with a focus on certain cancers, infectious diseases and CNS disorders such as Alzheimer's Disease.

Aphios employs a diverse range of individuals with expertise in the physical, chemical and biological sciences.

We seek entrepreneurial, qualified individuals who are passionate about health and wellness.

At Aphios Corporation, you will be part of a dynamic team dedicated to developing solutions for unmet medical needs, and improving quality of life, health and wellness.

Aphios offers competitive compensation packages and challenging positions with opportunities for career growth.

Careers at Aphios - Careers - About Us - Aphios

Chief Financial Officer

Fractional CFO

We are leading the way in developing green, enabling biotechnology and nanotechnology drug delivery platforms and enhanced therapeutic products for health maintenance, disease prevention and the treatment of certain cancers, infectious diseases and Central Nervous System (CNS) disorders such as Alzheimer's Disease.
 
Aphios®, which means "virus-free"​ in Greek, was founded in 1993 as a Delaware C corporation. The company was founded by Dr. Trevor P. Castor, President and CEO, to develop enabling technology platforms around the delivery and viral safety of biologics such as human plasma and recombinant therapeutics, hence its "virus-free"​ name. At its founding, the Company elected to spend about 10% of its research activities on investigating natural therapeutics. This interest has evolved to the realization that in order to solve the problems of cancer and aging, we have to look to nature, marine organisms and terrestrial plants that have learned how to control cell growth and cancerous mutation, often living for hundreds to thousands of years.

**Biotech IPO & Public-Markets Experience Required**

North Reading, MA (Hybrid / On-site as needed)

Clinical-Stage Biotechnology | Capital Markets | Executive Leadership

Part-Time / Fractional

**Job Code: APH-2601-01**

**Aphios Corporation** is a clinical-stage biotechnology company advancing differentiated nanotechnology platforms and next-generation therapeutics across oncology, neurodegenerative disease, infectious disease, and substance-use disorder.

As the company enters its **next phase of growth and capital-markets readiness**, Aphios is seeking an experienced **Part-Time / Fractional Chief Financial Officer (CFO)** with **direct biotech IPO and public-company preparation experience** to work closely with the CEO and Board.

This role is designed for a senior biotech finance executive who has **successfully guided companies through IPO preparation, public-company readiness, and alternative public-market pathways**, and who is interested in a **high-impact, flexible leadership engagement** rather than a full-time operating role.

**Key Responsibilities:**

- Lead financial strategy, capital planning, and cash-flow management for a growth-stage biotech
- Prepare the company for **IPO and public-company readiness**, including internal controls, reporting infrastructure, and governance
- Oversee GAAP-compliant financial reporting, audit readiness, and risk management
- Develop and maintain long-range financial models aligned with clinical, regulatory, and commercialization milestones
- Support **investor relations**, Board communications, and external stakeholder engagement
- Structure and evaluate **PIPE financings, crossover fund participation, and late-stage private capital strategies**
- Advise on **NASDAQ and NYSE uplisting requirements** and readiness timelines
- Evaluate **SPAC or de-SPAC-adjacent opportunities**, as appropriate, without over-engineering the business
- Interface with investment banks, auditors, securities counsel, and regulatory advisors
- Oversee grant accounting and compliance (e.g., NIH, SBIR/STTR)

**Qualifications:**

- Bachelor’s degree in Finance, Accounting, or related field*(MBA, CPA, or CFA strongly preferred)*
- **10–15+ years of senior financial leadership experience** in biotechnology or life sciences
- **Demonstrated experience taking a biotech company through IPO or IPO readiness**
- Strong working knowledge of **SEC reporting, GAAP, internal controls, and audit processes**
- Experience with **venture-backed, clinical-stage, or R&D-intensive organizations**
- Familiarity with **PIPEs, crossover investors, and public-market capital strategy**
- Executive presence with the ability to engage effectively at the **Board and investor level**
- Comfortable operating in **lean, entrepreneurial environments**

**Why This Role?**

- High-impact executive position with **direct influence on capital-markets strategy**
- Flexible, part-time / fractional engagement suitable for seasoned CFOs
- Opportunity to help position a differentiated biotech platform for **public-market execution**
- Mission-driven company with strong ESG alignment and meaningful therapeutic ambition

**To Apply:**

Qualified candidates (or trusted referrals) should send a **resume and brief cover note** referencing **Job Code: APH-2601-01** to: **[email protected]** **www.aphios.com**

Or mail to: **Dr. Trevor P. Castor** Aphios Corporation, 87 Main Street, North Reading, MA 01864

*No phone calls, please. Aphios Corporation is an equal opportunity employer.*

Fractional CFO

Job Description

About the Company

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